TTU HomeTechAnnounce

TechAnnounce

Printer friendly format
Purnendu K. Dasgupta Endowed Lectures
The TTU Chemistry & Biochemistry department will host Dr. R. Graham Cooks of Purdue University in a "Sandy" Dasgupta lecture series at the end of this month. Note that the "public" lecture on Tuesday, Oct 28 is open to the general public and will have catered refreshments available after the lecture. 

                Graham Cooks is a pioneer in the conception and implementation of the mass spectrometry methods of MS/MS and of desorption ionization. He has built mass spectrometers of various types, most recently miniature ion trap mass spectrometers, and applied them to problems of trace chemical detection. Some inventions and concepts to which Graham Cooks has contributed are ion soft landing, neutral loss scans, matrix based ionization, multiple reaction monitoring (MRM), hybrid mass spectrometers, handheld mass spectrometers, the kinetic method of thermochemical determination, tissue imaging and MS/MS for mixture analysis.

                Cooks is a past President of the American Society for Mass Spectrometry and the International Mass Spectrometry Society and a Life Member of the British Mass Spectrometry Society as well as the Japanese, Indian and Chinese societies. Several inventions have been commercialized and four companies launched from his lab.  He has published over a thousand papers, has an h-index of 83 and has served as major professor to 125 Ph. D. students.

 

Public lecture - 7 PM, Tuesday Oct 28, CHEM 049 

Chemical Analysis on Site: Mass Spectrometers in Operating Rooms, at Crime Scenes,  in Grocery Stores, along Factory Floors and on your Front Lawn

This presentation presents technology developed at Purdue University for rapid molecular analysis.  It uses miniature mass spectrometers combined with ion generation without sample work-up. The results are specific, sensitive, speedy and accurate.  There is marvelous math, fascinating physics and cool chemistry behind the development of these tools.  The underlying science deals with direct, rapid and chemically specific analysis of complex mixtures. The technology is applicable in food safety, public safety, drug discovery, therapeutic monitoring, environmental protection, and other areas. Examples of these applications and the underlying principles will be given with emphasis on cancer diagnostics and drug detection.   

 

Scientific Lecture - 12, Noon, Wednesday Oct 29, AGED (Agricultural Education) 102

Chemical and Materials Synthesis with the Mass Spectrometer

R. Graham Cooks, Chemistry Department, Purdue University, West Lafayette Indiana

The use of mass spectrometry to prepare macroscopic amounts of chemicals is traced to the soft landing experiment in which mass-selected polyatomic ions are decelerated and softly landed on a suitable surface.[1] This experiment has been successful with simple organic ions as well as with simple proteins.[2]  It is also possible to use gas phase ions to react at surfaces so as to create new surfaces.[3]  Both these experiments can be done with spatial control…..to write patterns on surfaces. 

The recent development of ambient ionization sources has greatly extended preparative experiments.  Ions generated in a mass spectrometer are used to make macroscopic amounts of materials, either on surfaces or in bulk.  In one experiment noble metals are electrolyzed in organic solvents and electrosprayed onto a surface. The metal ion containing droplets evaporate and are reduced to the metal and form crystalline nanoparticles.[4] The nanoparticles serve as SERS substrates which are readily generated, are stable in air and give good enhancement factors.  A lithographic version of the experiment uses metal ion focusing to write patterns on surfaces with selected materials.[5]

In the second type of experiment, organic reaction mixtures are electrosprayed and accelerated reactions occur in the fine sprayed droplets. The experiment has been used to generate products of the Claisen-Schmidt,[6] Hantzsch [7] and Katritsky reactions, in amounts (100’s mg) that allow characterization by NMR and other standard methods.  The experiment is easy to set up in an undergraduate organic chemistry lab [8] and has didactic value because students can quickly (minutes) run through a set of related syntheses, for example to study substituent effects. 

[1] S. A. Miller, H. Luo, S. J. Pachuta and R. G. Cooks, "Soft-Landing of Polyatomic Ions at Fluorinated Self-Assembled Monolayer Surfaces", Science, 275 1447 (1997) [2] Zheng Ouyang , Zoltan Takats, Thomas A. Blake, Bogdan Gologan, Andy J. Guymon, Justin M. Wiseman, Justin C. Oliver, V. Jo Davisson, R. Graham Cooks “Preparing Protein Microarrays by Soft Landing of Mass-Selected Ions” Science 2003, 301, 1351-1354. doi: 10.1126/science.1088776 [3] Jobin Cyriac, T. Pradeep, H. Kang, R. Souda, and R. G. Cooks,“Low-Energy Ionic Collisions at Molecular Solids”  Chemical Reviews, 2012, 112, 5356–5411. DOI: 10.1021/cr200384k [4] Anyin Li, Qingjie Luo,So-Jung Park and R. Graham Cooks, “Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals”   Angew. Chem. Int. Ed., 2014, 53, 3147–3150. DOI: 10.1002/anie.201309193 [5] A. Li, Z. Baird, S. Bag, D. Sarkar, A. Prabhath, T. Pradeep, R. G. Cooks, “Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy”  Angewandte Chemie , 2014, online. DOI: 10.1002/ange.201406660 [6] Thomas Müller, Abraham Badu-Tawiah and R. Graham Cooks, “Accelerated C-C Bond Forming Reactions in Preparative Electrospray”  Angew. Chem. Int. Ed., 2012, 51, 11832-11835. DOI: 10.1002/anie.201206632 [7] R. M. Bain, C. J. Pulliam, R. G. Cooks, “Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates”  Chemical Science , 2014, online. DOI: 10.1039/C4SC02436B [8] Ryan M. Bain, Christopher J. Pulliam, Xin Yan, Kassandra F. Moore, Thomas Müller, R. Graham Cooks “Mass Spectrometry in Organic Synthesis: Claisen-Schmidt Base-Catalyzed Condensation and Hammett Correlation of Substituent Effects” J Chem.Educ. in press 

Posted:
10/13/2014

Originator:
Robert Long

Email:
robert.long@ttu.edu

Department:
Chemistry

Event Information
Time: 7:00 PM - 8:30 PM
Event Date: 10/28/2014

Location:
CHEM 049


Categories